5 Reasons Why Your Business Needs Berberine Hydrochloride Exporter?
Berberine Supplement Market Size and Share | Statistics
Berberine Supplement Market Outlook ( to )
chenlv Product Page
According to projections made by Fact.MR regarding the global berberine supplement market, it is anticipated to reach a value of US$ 897.6 million in and witness a surge to US$ 2.05 billion by the conclusion of , reflecting a CAGR of 8.6% over the forthcoming decade.
The increasing consumer recognition of natural health supplements and their possible advantages is propelling the rise in berberine supplement consumption. Berberine is a compound present in various plants like Oregon grape, barberry, and goldenseal, and has garnered considerable attention due to its prospective health benefits, particularly regarding heart health and blood sugar management. It is currently becoming favored as a viable alternative to traditional medications for heart-related issues.
Metabolic diseases (e.g., diabetes, obesity, and non-alcoholic fatty liver disease) and cardiovascular diseases (including atherosclerosis, myocardial infarction, hypertension, cardiac hypertrophy, and heart failure) stand as the two primary global causes of morbidity and mortality.
- As per a study backed by the National Center for Complementary and Integrative Health, participants on metformin combined with a goldenseal supplement exhibited a 25% decrease in their blood levels of the diabetes medication (notably, goldenseal contains berberine).
This suggests that berberine may enhance blood sugar regulation in individuals diagnosed with type 2 diabetes who are undergoing treatment with metformin or other diabetes medications. Researchers have also associated the weight loss attributes linked to berberine's antioxidant properties with its capability to inhibit fat cell development.
Key Market Growth Drivers
- More consumers are opting for natural alternatives to treat a variety of medical conditions over traditional pharmaceuticals.
- The prevalence of diseases such as diabetes, obesity, and cardiovascular ailments prompts consumers to search for dietary supplements promising health benefits.
- Notable health benefits of berberine, including its potential to mitigate heart disease risks, aid in weight management, and stabilize blood sugar and cholesterol levels, significantly influence the growing demand for berberine supplements.
- The wide availability of such supplements across multiple distribution channels such as pharmacies, health food outlets, and online retail sites accelerates market growth.
- Berberine supplements play a pivotal role in managing chronic health issues prevalent among the aging demographic.
- The credibility and safety of berberine supplements are increasingly recognized by regulatory organizations in various regions.
What are the Key Berberine Supplement Market Trends?
Firms Advocating the Benefits of Berberine Supplements Effectively
Growing awareness among consumers about the potential health advantages of berberine supplements—particularly concerning diabetes, high cholesterol, and obesity—has positively impacted sales. Manufacturers are innovating to distinguish their products from competitors, introducing new formulations such as combination products with complementary ingredients for enhanced efficacy or sustained-release capsules.
Companies are utilizing specific marketing strategies to engage targeted consumer groups interested in natural health supplements for diabetes management. By adjusting marketing tactics to align with their target demographics, businesses can considerably boost the promotion of their berberine supplements and enhance revenue streams. Recent studies have also highlighted berberine's potential role as a pharmaceutical intervention for obesity.
- A study cited in ScienceDirect indicates that berberine stops fat accumulation in both human and murine adipocytes, significantly reducing body weight, body mass index, and visceral fat, while also lowering levels of C-reactive protein.
Which Obstacles are Impeding Market Expansion?
Lack of FDA Regulation for Berberine Supplements
Health professionals advise caution against the use of berberine until its potential health benefits can be scientifically substantiated, alongside assessments of its safety and effectiveness for various health issues.
Potential side effects such as constipation, headaches, rash, nausea, and stomach upset can arise with berberine. Additionally, interactions with prescription drugs like those aimed at lowering blood sugar could lead to adverse effects.
Since dietary supplements like berberine are not regulated by the U.S. FDA, the concentration of active ingredients in products remains uncertain. Consequently, the composition of berberine supplements can vary significantly, causing confusion regarding appropriate dosages. Furthermore, berberine use during pregnancy and in newborns may pose risks.
Country-wise Insights
In , Japan has emerged as a significant exporter of berberine chloride. Given that berberine chloride is a hydrochloride and ammonium salt variant of the herb, its applications extend to tackling diabetes and inflammation. Based on the export statistics from Japan, the nation was the primary supplier of berberine chloride to India in .
Berberine enjoys widespread utilization in Asian countries, primarily in China, thanks to its excellent clinical and safety profile. With significant advancements in pharmacological research, berberine is recognized as one of the most promising drug candidates derived from natural products for treating cardiovascular and metabolic diseases.
For additional details regarding Berberine Hydrochloride Exporter, please reach out to us for expert assistance.
Why are Sales of Berberine Supplements High in China?
Long History of Berberine in Diabetes Treatment
In China, the expansion of the berberine supplement market is significantly influenced by its longstanding usage in herbal and traditional Chinese medicine. Berberine has been utilized for decades in the treatment of diabetes, with a recorded increase of 10.5% year-over-year in diabetes cases among the populace in .
- A clinical trial involving 409 participants by Premote revealed that when combining berberine and probiotic powder, patients experienced lowered blood sugar levels.
Why are Berberine Supplement Providers Investing in the United States?
Shift towards Herbal Remedies Amid Fears about Conventional Drug Side Effects
In the United States, retail sales of vitamin and mineral products reported a modest annual growth rate of approximately 1% during the period from to .
- A survey conducted by the Council for Responsible Nutrition (CRN) found that 69% of adults in the U.S. consume dietary supplements to remedy nutritional deficiencies.
As berberine is classified as a dietary supplement, the rise in demand for nutritional products is poised to substantially foster market growth. Being an alkaloid compound found across multiple herbs, berberine is benefitting from an overall trend focused on natural alternatives due to increasing concerns over the side effects of pharmaceutical drugs.
Category-wise Insights
The berberine supplement market is on the rise due to consumers favoring quick-absorbing, vegan-friendly products, alongside the recognized benefits of berberine in managing diverse health issues.
Why are Online Sales of Berberine Supplements Rising Rapidly?
Extensive Availability Through e-Commerce Platforms
Typically priced between US$ 15 and US$ 40 for a month's supply, berberine supplements are easily accessible online. Despite certain countries, including the United States, lacking locally grown plants containing berberine, these supplements remain widely accessible through online channels. The increasing inclination toward natural alternatives and higher health consciousness among netizens further drives the demand for berberine supplements.
Why Do Tablets Dominate the Berberine Supplement Market?
Rapid Absorption by the Body Fuels Preference for Tablets
The demand for berberine supplements in tablet form is witnessing a pronounced uptick due to their quick absorption characteristics, making them the favored choice among numerous consumers. Tablets facilitate consistent dosing, ensuring that users effectively gain the desired benefits.
The ongoing trend of consumers shifting toward plant-based and vegan products also enhances the popularity of berberine capsules, which align with these preferences.
Leading Market Players
Key players in the berberine supplement sector include Solaray, Zhou Nutrition, Swanson Health, Sunergetic, Best Naturals, Horbaach, Thorne, Toniiq, Now Foods, Amazing Nutrition, and Dr. Martin's Nutrition.
Segmentation of Berberine Supplement Market Research
-
By Form :
- Caplets
- Capsules
- Liquid
- Powder
- Softgel
- Tablets
-
By Sales Channel :
- Online
- Retail
-
By Region :
- North America
- Europe
- Latin America
- East Asia
- South Asia & Oceania
- Middle East & Africa
Berberine: A Review of its Pharmacokinetics Properties ...
Traditional Chinese medicine has become increasingly relevant in treating various ailments, drawing considerable interest for clinical applications. Vascular illnesses impacting the heart, cerebrovascular diseases, atherosclerosis, and complications arising from diabetes compromise the quality of life for many and elevate healthcare burdens. Berberine, an isoquinoline alkaloid sourced from Rhizoma coptidis, is extensively utilized in China as folk medicine due to its antibacterial and anti-inflammatory properties. Encouragingly, a growing body of research has indicated several cellular and molecular targets associated with berberine, substantiating its role as an alternative therapeutic option for vascular disorders and providing evidence of its efficacy against these conditions. This review aims to present a thorough systematic assessment of the evidence supporting berberine as a therapeutic agent for vascular diseases, which will encompass its pharmacological effects, mechanism of action, and pharmacokinetic profiles. Existing research illustrates that berberine possesses significant anti-inflammatory, antioxidant, anti-apoptotic, and anti-autophagic activity through the modulation of multiple signaling pathways, including AMP-activated protein kinase (AMPK), nuclear factor κB (NF-κB), SIRT-1, hypoxia-inducible factor 1α (HIF-1α), PI3K, Akt, JAK-2, Ca 2+ channels, and endoplasmic reticulum stress. Additionally, we tackle the inherent limitations posed by berberine in treating vascular diseases and offer potential solutions. We also outline research perspectives and prevailing challenges while providing a robust foundation from which future studies can draw on to discover novel effective medications derived from components of traditional Chinese medicine.
In recent times, unique molecular entities isolated from herbal medications containing berberine have sparked growing attention regarding the compound's potential in addressing vascular disease (Lee et al.,; Ren et al.,; Rajabi et al.,). Alongside advancements in pharmaceutical research, berberine is deemed a highly promising natural compound aimed at treating numerous human vascular diseases by modulating several signaling pathways. However, there lacks a comprehensive review delineating the pharmacological and pharmacokinetic properties of berberine within the framework of vascular disease. Consequently, we filtered through relevant studies on berberine's influence on vascular diseases published from years using databases such as Web of Science, ScienceDirect, PubMed, Google Scholar, and China National Knowledge Infrastructure to consolidate our findings, thereby providing insights into berberine’s application for treating vascular diseases.
Pharmacokinetics of Berberine
Distribution
Research demonstrates that berberine distributes rapidly across various tissues, including the liver, kidneys, muscle, lungs, brain, heart, pancreas, and adipose tissue, with the concentration in most tissues exceeding that found in plasma four hours after administering an oral dose of 200 mg/kg in rats. Additionally, berberine concentrations remain relatively stable in liver, heart, brain, muscle, and pancreatic tissues in rats (Tan et al.,). However, recent investigations focused on the in vivo distribution of berberine remain scarce, often attributed to its broad tissue distribution post-oral administration. The availability of novel methodologies, such as high-performance liquid chromatography combined with electrospray ionization mass spectrometry (HPLC-ESI/MS) and mass spectrometry imaging, could facilitate improved exploration of the tissue distribution of berberine (Jove et al.,). The extensive distribution of berberine across tissues presents an opportunity for its use in treating various ailments while broadening the scope of its clinical applications. For example, oral administration of 100 mg/kg berberine can encourage the excretion of cholesterol from liver to bile (Li et al., b). Accordingly, berberine's tissue distribution embodies a crucial pharmacokinetic characteristic that warrants additional research in the future.
Metabolism
One investigation utilized a sensitive HPLC-ESI/MS method to track the metabolites of berberine in human plasma, revealing that berberrubine was the most prevalent, displaying high lipid solubility in individuals who ingested an oral dose of 15 mg/kg of berberine chloride daily for three months (Spinozzi et al.,). Evidence suggests a similar metabolic profile for berberine exists in both rats (100 mg/kg administered orally) and humans (300 mg taken orally three times a day over two days) via urine (Qiu et al.,). Utilizing liquid chromatography in conjunction with ion trap time-of-flight mass spectrometry, Ma et al. () identified 16 distinct metabolites present in rat bile, urine, and fecal samples derived from oral berberine (200 mg/kg). Subsequent oral administrations of varying doses (48.2, 120, or 240 mg/kg) indicated that the levels of phase II metabolites surpassed those of phase I metabolites for the AUC0-48h values. Simultaneously, nine principal metabolites of berberine (including demethyleneberberine and jatrorrhizine-3-O-β-D-glucuronide) were detected within rat serum via an LC-MS/MS approach (Feng et al.,). Furthermore, the metabolism of berberine via oral ingestion is closely intricately linked to liver function and gut microbiota. Following the oral administration of 300 mg/kg berberine to mice, levels of cytochrome P3A11 (CYP3A11), CYP3A25 mRNA, and CYP3A11 and CYP2D22 enzyme activity were found to have decreased, while the CYP1A2 mRNA levels were heightened (Guo et al.,). Similarly, oral consumption of 200 mg/kg berberine results in metabolism by the liver through CYP450 isoenzymes involving oxidative demethylation at C2, C3, C9, and C10, which is succeeded by the conjugation of hydroxyl groups with glucuronic acid (Singh et al.,). Moreover, gut microbiota significantly affects berberine's metabolism post-oral ingestion, as indicated by studies where 200 mg/kg berberine administered orally was transformed into absorbable dihydroberberine by nitroreductases produced by gut microbiota, exhibiting nearly five times higher intestinal absorption rates than berberine in rats; subsequently, dihydroberberine converts back to berberine upon absorption into intestinal tissue before entering the bloodstream (Feng et al.,; Han et al., a). Additionally, in vitro and in vivo observations indicate that gut microbiota can oxidize berberine to form oxyberberine, which has a notably stronger binding affinity to hemoglobin compared to plasma (Li et al., a; Chen et al.,).
In summary, the liver and intestines serve as the primary metabolic organs for berberine administered orally. Inhibiting first-pass metabolism may enhance its bioavailability. Notably, thorough investigations regarding berberine's metabolism in vivo reveal that phase II metabolites predominate as the primary metabolic products (Feng et al.,), contradicting previous studies (Ma et al.,). Future research must give due attention to the role of nitroreductases from gut microbiota and the overall metabolism of berberine to thoroughly establish its pharmacodynamic foundation as a component of traditional Chinese medicine.
Excretion
To ascertain the poor absorption characteristics of berberine in vivo, researchers have focused on its excretion in relation to digestive health. Following a single oral dose (200 mg/kg), subsequent studies found that berberine was present in fecal matter with a recovery rate of 22.74% recorded within 48 hours, with thalifendine being the most prevalent metabolite excreted in bile, urine, and feces in rats (Ma et al.,). A separate investigation indicated that 18.6% of berberine was excreted through feces as berberrubine following an intragastric administration at a dose of 48.2 mg/kg. Notably, the cumulative recovery of berberine along with its metabolites from urine, bile, and feces reached 41.2% in rats (Feng et al.,). To condense, berberine and its metabolites are predominantly excreted by the kidneys (urine and feces) and bile in rodents.
If you desire further insights, kindly visit Green Tea Extract Powder.
- 0